Ensuring integrity in gametogenesis

To ensure the creation of new individuals

The creation of new individuals is the basis for perpetuating the species. The gametes are the sole cell types that can achieve this purpose through the transmission of genetic and epigenetic information into the next generation. Since the quality of the gametes is essential to ensure healthy and fertile individuals, gametogenesis must be a robust process that produces functional gametes. We aim to understand how the “integrity” of gametes is constructed in vivo and how to reconstitute it in vitro.

Research Contents

  • A01

    Reconstitution of gamete-integrity in vitro gametogenesis using pluripotent stem cells

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  • A01

    Establishment of in vitro spermatogenesis with high integrity

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  • A01

    Establishment of in vitro oogenesis with high integrity

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  • A01

    Adaptation of in vitro gametogenesis across a wide range of species

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  • A01

    Effect of luminal fluid flow on spermatogenesis in vitro

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  • A01

    Establishment of a versatile culture system for in vitro egg production

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  • A01

    Establishment of a robust culture system from Drosophila germline stem cells.

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  • A02

    Predictive analysis of oocyte integrity with chromosome imaging

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  • A02

    Prediction of gamete-integrity by minimally invasive optical probe

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  • A02

    Development of evaluation technique for gamete integrity by optical coherence tomography system

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  • A02

    Single gamate proteomics for identification of gameto-integrity marker

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  • A02

    Development of genomics and transcriptomics for understanding acquisition of hyper transcription state

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  • A02

    Development of Spatial Multi-Omics Analysis Technology toward Understanding the High Transcription State

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  • A02

    Analysis of molecular basis of lipid droplet biogenesis on oocyte integrity

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  • A03

    Analysis of repertoire dynamics of germ cell development

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  • A03

    Mechanism regulating "germline selection" in germ cell development

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  • A03

    Single-cell transcriptome dynamics linked with histology of in vivo/in vitro gametogenesis

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  • A03

    Research on the novel mechanisms involved in planarian reproductive strategy

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  • A03

    Elucidating the role of hormones and neurotransmitters in the regulation of germline stem cell integrity

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  • A03

    Roles of luminal fluid flow of the seminiferous tubule in high integrity of mammalian spermatogenesis in vivo

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  • A03

    Metabolic control for ensuring integrity in male fetal germline differentiation

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  • A03

    Role of cytoplasmic RNP granules in the activation and the sustainability of primordial follicles

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  • A03

    Establishment and the regulation of germline cell integrity by symbiotic bacteria

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  • A03

    The mechanisms of Wnt-mediated primordial follicle activation

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  • A03

    Oocyte Integrity Regulated by Vesicle Transport

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  • A03

    Studies on mechanism of age-related loss of mutant mitochondrial DNA from germline cells

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  • A03

    Integrity of gametogenesis by integration of hormonal and neurotransmitter signals

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  • A03

    Roles of luminal fluid flow of the seminiferous tubule in high integrity of mammalian spermatogenesis in vivo

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  • A03

    Elucidation of Lipid Molecules Involved in Sperm Integrity

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  • A03

    Sperm Integrity during capacitation

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  • A03

    Design principles of reproductive tract luminal environment to regulate sperm maturation

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  • A03

    Regulation of cell fate decision during mammalian spermatogenesis

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  • A03

    Elucidation of the roles of mini-puberty in spermatogenesis

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  • A03

    Development of in vivo live imaging of primordial follicles for understanding their heterogeneity and activation

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